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Found 258 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Fgr'
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50354486(CHEMBL411043)
Affinity DataKi:  3.47E+3nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataKi:  7.74E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50:  0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50:  0.400nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50601440(CHEMBL5176837)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.658nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM13268(BMS-354825 2-Heteroarylamino-thiazole Analog 12m |...)
Affinity DataIC50: <1nMAssay Description:Inhibitory activity against Fgr kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of FGRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human FGR using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50151366((2-Chloro-6-methyl-phenyl)-[8-((S)-3-methyl-pipera...)
Affinity DataIC50: >2.80nMAssay Description:Inhibition of Fgr protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50:  3.70nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM473174((3S,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50: <5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM473171((3R,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50: <5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM473172((3R,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50: <5nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50571039(CHEMBL4877846)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  8nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184785(CHEMBL3823620 | US10294227, Code 553)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184786(CHEMBL3824116 | US10294227, Code 565)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM387854(US10294227, Code 584)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184782(CHEMBL3824228 | US10294227, Code 543)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184781(CHEMBL3823543 | US10294227, Code 533)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184777(CHEMBL3823104 | US10294227, Code 519)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184776(CHEMBL3824233 | US10294227, Code 518)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM387846(US10294227, Code 503)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM387836(US10294227, Code 585 | tert-butyl N-[4-[4-amino-1-...)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184767(CHEMBL3824089 | US10294227, Code 506)
Affinity DataIC50: <10nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM230107(US10106559, Example 33 | US10435415, Example 33 | ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50269558(CHEMBL4077588)
Affinity DataIC50:  22nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50560327(CHEMBL4749037)
Affinity DataIC50:  26nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM452963(US10711006, Compound I)
Affinity DataIC50:  27nMAssay Description:Preparation of Compounds to be Tested:1) Using DMSO to prepare 50× compound stock solutions (same as the stock solution in Example 34) for later use;...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM267959(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50:  28nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50511997(CHEMBL4525187)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant FGR using Ulight-TK peptide as substrate measured after 60 mins in the presence of ATP by LANCE methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50446982(CHEMBL3116050)
Affinity DataIC50:  33nMAssay Description:Inhibition of human FgrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM255303(US9481682, 52)
Affinity DataIC50:  34nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM267790(4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50269555(CHEMBL4060757)
Affinity DataIC50:  39nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50577406(CHEMBL4862806)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant FGR (456 to 770) radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant FgrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM473175((3S,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50:  52nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184778(CHEMBL3823711 | US10294227, Code 540)
Affinity DataIC50:  55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50558112(CHEMBL4799627)
Affinity DataIC50:  55nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universit£T

Curated by ChEMBL
LigandPNGBDBM50184780(CHEMBL3823255 | US10294227, Code 526)
Affinity DataIC50:  55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair
In DepthDetails US Patent
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