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Found 3315 Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 5'
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597886(CHEMBL5180177)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to PRMT5 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572983(CHEMBL4848846)
Affinity DataKi:  2.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572968(CHEMBL4862851)
Affinity DataKi:  8.00E+3nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572964(CHEMBL4867592)
Affinity DataKi:  1.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572989(CHEMBL4846332)
Affinity DataKi:  3.60E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572991(CHEMBL4858967)
Affinity DataKi:  4.20E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572990(CHEMBL4859105)
Affinity DataKi:  4.90E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572988(CHEMBL4855695)
Affinity DataKi:  5.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572984(CHEMBL4874198)
Affinity DataKi:  7.80E+4nMAssay Description:Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597880(CHEMBL5203719)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5 expressed in Sf9 insect cells using histone H2A as peptide after 120 mins in presence of...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523646(CHEMBL4541714)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597881(CHEMBL5187591)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523641(CHEMBL4543007)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM435525((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...)
Affinity DataIC50:  0.5nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM435509((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  0.75nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM435657((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...)
Affinity DataIC50:  0.800nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM435523((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...)
Affinity DataIC50:  0.850nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM435710((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  0.900nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataIC50:  1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523661(CHEMBL4547524 | US10709709, Example 154)
Affinity DataIC50:  1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523654(CHEMBL4455651 | US10709709, Example 212)
Affinity DataIC50:  1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451383(US10709709, Example 213 | US10709709, Example 214)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451385(US10709709, Example 215 | US10709709, Example 216)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451385(US10709709, Example 215 | US10709709, Example 216)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM452998((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM452999((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM452998((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM452999((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50595702(CHEMBL5172637)
Affinity DataIC50:  1nMAssay Description:Inhibition of PRMT5 methyltransferase activity in human MTAP -/- Calu-6 cells assessed as reduction in SmB SDMA levels measured after 2 days by HTRF ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415554((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415556(US10428104, Example 87)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM430630(US10550096, Example 3)
Affinity DataIC50:  1nMAssay Description:The cell line TE11 was seeded at a density of 6,000 cells per well in 96 well optical quality tissue culture plates in DME medium and 10% foetal bovi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451251(US10709709, Example 78)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415582(US10428104, Example 112)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451261(US10709709, Example 88)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523652(CHEMBL4445368 | US10709709, Example 89)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523650(CHEMBL4541232 | US10709709, Example 91)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451265(US10709709, Example 92)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451266(US10709709, Example 93)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451267(US10709709, Example 94)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451273(US10709709, Example 100)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451274(US10709709, Example 101)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451275(US10709709, Example 102)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM451276(US10709709, Example 103)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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