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Found 15 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase SETDB1'
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of SETDB1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50063670(CHEMBL3397332)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETDB1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETDB1 (unknown origin) assessed as incorporation of tritium-labeled methyl group to lysine or arginine residues of peptide substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521988(CHEMBL4456448)
Affinity DataKd:  1.27E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521989(CHEMBL4453131)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521990(CHEMBL4576037)
Affinity DataKd:  3.50E+6nMAssay Description:Binding affinity to N-terminal His6-tagged human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by IT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521990(CHEMBL4576037)
Affinity DataKd:  3.50E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521987(CHEMBL4542222)
Affinity DataKd:  2.70E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521992(CHEMBL4455427)
Affinity DataKd:  2.50E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521989(CHEMBL4453131)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to N-terminal His6-tagged human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by IT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521986(CHEMBL4451286)
Affinity DataKd:  1.00E+7nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50521991(CHEMBL4589361)
Affinity DataKd:  7.70E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed