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Found 151 Enz. Inhib. hit(s) with Target = 'Squalene monooxygenase'
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataKi:  30nMAssay Description:Apparent inhibitory constant of the compound against squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50286540(1N-[20-(6-aminohexylamino)-4,8,13,17-tetramethyl-(...)
Affinity DataKi:  2.40E+3nMpH: 8.8Assay Description:The compound was tested for its inhibitory activity against pig Squalene epoxidase at pH 7.4More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50279929((2Z,6E,10E,14E)-6,11,15,19-Tetramethyl-2-(4-methyl...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory activity of the compound was measured against partially purified pig liver Squalene epoxidase (SE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018524(6,10,15,19,23-Pentamethyl-tetracosa-6,10,14,18,22-...)
Affinity DataKi:  9.50E+5nMAssay Description:Apparent inhibitory constant of the compound against squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018522(6,10,15,19-Tetramethyl-tetracosa-6,10,14,18-tetrae...)
Affinity DataKi:  1.00E+6nMAssay Description:Inhibitory activity against Candida albicans Squalene EpoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044104((6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-ph...)
Affinity DataIC50:  0.5nMAssay Description:Tested in vitro in rat liver squalene synthase assay (RLSS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044103((6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-ph...)
Affinity DataIC50:  0.660nMAssay Description:Tested in vitro in rat liver squalene synthase assay (RLSS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044100((6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-ph...)
Affinity DataIC50:  0.870nMAssay Description:Tested in vitro in rat liver squalene synthase assay (RLSS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044102((6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-ph...)
Affinity DataIC50:  1.80nMAssay Description:Tested in vitro in rat liver squalene synthase assay (RLSS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044101((6S,7R)-1-((R)-4-Acetoxy-5-methyl-3-methylene-6-ph...)
Affinity DataIC50:  4.5nMAssay Description:Tested in vitro in rat liver squalene synthase assay (RLSS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032850(CHEMBL27885 | [3-([3,3']Bithiophenyl-5-ylmethoxy)-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032836(4-[(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]-...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032836(4-[(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032843(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032843(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-...)
Affinity DataIC50:  30nMAssay Description:Compound was evaluated for the inhibition of pig liver microsomal squalene epoxidase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032853(2-[(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070340(CHEMBL281025 | Thiophene-2-sulfonic acid [2-(3-{[(...)
Affinity DataIC50:  50nMAssay Description:Compound was evaluated in vitro for the inhibition of pig liver squalene epoxidase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032856(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-(3-{[(4-...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070340(CHEMBL281025 | Thiophene-2-sulfonic acid [2-(3-{[(...)
Affinity DataIC50:  60nMAssay Description:Compound was evaluated for inhibitory activity against cholesteryl ester transfer proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50093887(3,4,5-Trihydroxy-benzoic acid dodecyl ester | CHEM...)
Affinity DataIC50:  61nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant rat SE(squalene epoxidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50093887(3,4,5-Trihydroxy-benzoic acid dodecyl ester | CHEM...)
Affinity DataIC50:  61nMAssay Description:Inhibition of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032837(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-(3-{[dimethyl-...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032830(CHEMBL107568 | {3-[(Dimethyl-o-tolyl-silanyl)-meth...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032847(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-(3-{[dimethyl-...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070340(CHEMBL281025 | Thiophene-2-sulfonic acid [2-(3-{[(...)
Affinity DataIC50:  80nMAssay Description:Compound was evaluated for inhibitory activity against cholesteryl ester transfer protein, reported from fungusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070337(CHEMBL27154 | [3,3']Bithiophenyl-5-sulfonic acid [...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032848((6,6-Dimethyl-hepta-2,4-diynyl)-{3-[(dimethyl-o-to...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070344(CHEMBL26950 | Thiophene-2-sulfonic acid [2-(3-{[((...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50288841((3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-ami...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for the inhibition of pig liver microsomal squalene epoxidase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50291660(CHEMBL16178 | [3-([3,3']Bithiophenyl-5-ylmethoxy)-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]-...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032834(4-[(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281098(2,2-dimethyl-3-[3,7,12-trimethyl-14-[3-methyl-3-(4...)
Affinity DataIC50:  110nMAssay Description:Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032832(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240891(2-(2-{6-[5,7-dihydroxy-3-(3,4,5-trihydroxyphenylca...)
Affinity DataIC50:  130nMAssay Description:Inhibition of rat squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032842(CHEMBL108144 | {3-[(Benzyl-dimethyl-silanyl)-metho...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032840(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-(3-{[(2-...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032844(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-{3-[(dimethyl-...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070341(CHEMBL26151 | Pyridine-3-sulfonic acid [2-(3-{[((E...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070343(CHEMBL26596 | Thiazole-2-sulfonic acid [2-(3-{[((E...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070345(CHEMBL26964 | Thiophene-2-sulfonic acid [2-(3-{[((...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070331(4-Cyano-N-[2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-yn...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070350(CHEMBL284197 | N-[2-(3-{[((E)-6,6-Dimethyl-hept-2-...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070346(CHEMBL27941 | [2,3']Bithiophenyl-5-sulfonic acid [...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50032835((3-{[(4-Bromo-phenyl)-dimethyl-silanyl]-methoxy}-b...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibitory activity against pig liver microsomal squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070342(CHEMBL26077 | Thiophene-2-sulfonic acid cyclopropy...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070349(CHEMBL26597 | Thiophene-3-sulfonic acid [2-(3-{[((...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070333(CHEMBL281666 | N-[2-(3-{[((E)-6,6-Dimethyl-hept-2-...)
Affinity DataIC50:  255nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50291661(CHEMBL267332 | [3-(3-Azido-phenyl)-prop-2-ynyl]-[3...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of pig liver microsomal squalene epoxidase (SE) by measuring the extend of cholesterol radiolabeling after incubation with [14C]-...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070348(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-{3-[3-(t...)
Affinity DataIC50:  290nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50070339(4-Bromo-thiophene-2-sulfonic acid [2-(3-{[((E)-6,6...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of cholesterol biosynthesis in human HepG2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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