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Found 465 Enz. Inhib. hit(s) with Target = 'Thioredoxin'
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385299(CHEMBL2035464 | US8592468, EbSe16)
Affinity DataKi:  10nM IC50:  2.25E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385302(CHEMBL2035461 | US8592468, EbSe15)
Affinity DataKi:  40nM IC50:  2.10E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385303(CHEMBL2035460 | US8592468, EbSe14)
Affinity DataKi:  50nM IC50:  2.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182122(CHEMBL204688 | bis(2,4-dinitrophenyl)sulfane)
Affinity DataKi:  200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106948(US8592468, EbSe12)
Affinity DataKi:  250nM IC50:  3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106941(US8592468, EbSe8)
Affinity DataKi:  250nM IC50:  6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase 3(Homo sapiens (Human))
National University Of Ireland

Curated by ChEMBL
LigandPNGBDBM50179991(CHEMBL3814977)
Affinity DataKi:  280nMAssay Description:Irreversible inhibition of thioredoxin reductase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataKi:  300nM IC50:  6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206464(CHEMBL3926452)
Affinity DataKi:  390nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106940(US8592468, EbSe7)
Affinity DataKi:  550nM IC50:  7.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  650nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206462(CHEMBL3913125)
Affinity DataKi:  680nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206460(CHEMBL3968421)
Affinity DataKi:  690nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206468(CHEMBL3976958 | US10300048, ETI-T-193)
Affinity DataKi:  730nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106944(US8592468, EbSe2)
Affinity DataKi:  1.00E+3nM IC50:  1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50182128(4-nitrobenzo[c][1,2,5]thiadiazole | CHEMBL383084)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206465(CHEMBL3957420)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106942(US8592468, EbSe9)
Affinity DataKi:  1.20E+3nM IC50:  7.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin, mitochondrial(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataKi:  1.31E+3nMAssay Description:Inhibition of human recombinant TRX-2 up to 60 mins by insulin reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106949(US8592468, EbSe13)
Affinity DataKi:  1.50E+3nM IC50:  3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50333880(CHEMBL1614664 | Hypericin | Pseudohypericin)
Affinity DataKi:  1.90E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206458(CHEMBL3939464)
Affinity DataKi:  2.07E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206470(CHEMBL3930972)
Affinity DataKi:  2.82E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206467(CHEMBL516894)
Affinity DataKi:  2.88E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataKi:  3.11E+3nMAssay Description:Inhibition of human recombinant TRX-1 up to 60 mins by insulin reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206466(CHEMBL3986107)
Affinity DataKi:  3.16E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50375309(BAY-5360 | Flagyl | Flagyl 375 | Flagyl ER | Flagy...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206456(CHEMBL3981295)
Affinity DataKi:  3.56E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206457(CHEMBL3906260)
Affinity DataKi:  4.66E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206472(CHEMBL3958486)
Affinity DataKi:  5.68E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206471(CHEMBL3968932)
Affinity DataKi:  6.23E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50333880(CHEMBL1614664 | Hypericin | Pseudohypericin)
Affinity DataKi:  8.10E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 at protein-substrate complex by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206469(CHEMBL3948765)
Affinity DataKi:  1.09E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206459(CHEMBL3957509)
Affinity DataKi:  1.61E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206463(CHEMBL3897298)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Entamoeba histolytica)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50206461(CHEMBL3941140)
Affinity DataKi:  3.37E+5nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501863(US11028067, Example 4)
Affinity DataIC50:  0.854nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522169(US11161815, Example 25)
Affinity DataIC50:  1.03nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522162(US11161815, Example 18)
Affinity DataIC50:  1.52nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM531217(US11208384, Example 1)
Affinity DataIC50:  3.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501865(US11028067, Example 6)
Affinity DataIC50:  3.99nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522165(US11161815, Example 21)
Affinity DataIC50:  4.35nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522166(US11161815, Example 22)
Affinity DataIC50:  5.05nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  5.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522173(US11161815, Example 29)
Affinity DataIC50:  6.78nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501866(US11028067, Example 7)
Affinity DataIC50:  6.90nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522164(US11161815, Example 20)
Affinity DataIC50:  7.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522171(US11161815, Example 27)
Affinity DataIC50:  7.33nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522163(US11161815, Example 19)
Affinity DataIC50:  7.60nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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