TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.00400nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0150nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0160nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nM ΔG°: -56.4kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Enzyme inhibitory activity towards Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -53.6kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibitory constant against rabbit lung Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 0.5nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity towards Angiotensin I converting enzyme of rat brain IgG immobilized enzyme.More data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
Affinity DataKi: 0.680nMAssay Description:Inhibition of human somatic ACE in presence of bufferMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nM ΔG°: -52.3kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme/Ribosomal RNA small subunit methyltransferase NEP1(Human)
Theravance Biopharma R&D Ip
US Patent
Theravance Biopharma R&D Ip
US Patent
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.20nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.20nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Compound was tested for its inhibitory potency against angiotensin I converting enzyme.More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.25nM ΔG°: -50.8kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition constant against angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibitory activity of the compound against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute
Curated by ChEMBL
Marion Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair