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Found 60 Enz. Inhib. hit(s) with Target = 'GTPase HRas'
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50097071(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to HRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human H-rasMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HRAS (unknown origin) farnesylationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089969(5-[Bis-(2-chloro-ethyl)-amino]-benzofuran-2-carbox...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089962(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-be...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089961(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089960(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089967(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089971(5-[Bis-(2-chloro-ethyl)-amino]-1-methyl-1H-indole-...)
Affinity DataIC50:  20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50089978(5-[Bis-(2-chloro-ethyl)-amino]-1H-indole-2-carboxy...)
Affinity DataIC50:  20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060139(CHEMBL326352 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  88nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601400(CHEMBL5171806)
Affinity DataIC50:  100nMAssay Description:Inhibition of HRAS (unknown origin) transfected in BALB/c nude mouse incubated for 3 days measured by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601398(CHEMBL5174384)
Affinity DataIC50:  100nMAssay Description:Inhibition of [35S]methionine labelled HRAS in rat Rat1 cells by immunoprecipitation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060141(CHEMBL431440 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-me...)
Affinity DataIC50:  180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060146(CHEMBL407445 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060140(CHEMBL115943 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-cy...)
Affinity DataIC50:  190nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50055659(2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-meth...)
Affinity DataIC50:  200nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060145(CHEMBL115669 | [(S)-1-{(4-Benzyloxy-benzyl)-[((S)-...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060138(CHEMBL324827 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Affinity DataIC50:  310nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060142(CHEMBL326127 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-p...)
Affinity DataIC50:  330nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060149(CHEMBL112512 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Affinity DataIC50:  400nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060150(CHEMBL114281 | [(S)-1-{(4-Benzyloxy-benzyl)-[((R)-...)
Affinity DataIC50:  570nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060144(CHEMBL325073 | [(S)-1-{(4-Benzyloxy-benzyl)-[((R)-...)
Affinity DataIC50:  710nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287960(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060148(CHEMBL325331 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-ph...)
Affinity DataIC50: >1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060152(CHEMBL112879 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-et...)
Affinity DataIC50: >1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287951(3-[(3aS,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50478506(Ophirapstanol Trisulfate)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of human recombinant p21RAS by GDPX assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287961((E)-5-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50059857(CHEMBL102955 | [(S)-1-[(4-Benzyloxy-benzyl)-(phene...)
Affinity DataIC50:  4.30E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287943((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287946(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50060143(CHEMBL324345 | [(S)-1-{(4-Benzyloxy-benzyl)-[((S)-...)
Affinity DataIC50:  6.30E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287963(CHEMBL300769 | [(2S,6R)-6-(4-Chloro-6-methoxy-3-me...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287959((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287955((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287958(CHEMBL303105 | [(2S,6R)-6-(4-Chloro-6-methoxy-3-me...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50072339(Benzodiazepine-Distamycin Hybrid | CHEMBL102341)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Ha-ras polymerase-chain reaction productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287945(5-(4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]q...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287944((E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methy...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287953(5-(4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]q...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287962(CHEMBL61870 | [(2S,6R)-4-Benzenesulfonyl-6-(4-chlo...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287949(1-[(2R,6S)-4-Benzenesulfonyl-6-(tert-butyl-dimethy...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287948(CHEMBL64886 | [(2S,6R)-6-(4-Chloro-6-methoxy-3-met...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50059879(CHEMBL102492 | [(S)-1-{(4-Benzyloxy-benzyl)-[(2-be...)
Affinity DataIC50:  1.43E+4nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287956(Benzoic acid (3aR,4R,6R,6aR)-6-(4-chloro-6-methoxy...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287947((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287952(CHEMBL304717 | N-{4-[(2S,6R)-2-(tert-Butyl-dimethy...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50287954((E)-3-[(2S,5R)-5-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of nucleotide exchange process of oncogenic Ras in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGTPase HRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601396(CHEMBL5197181)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of human p21 h-RAS assessed as reduction in C-Cdc25 stimulated nucleotide exchange by luminescence spectrometer based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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