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Found 422 Enz. Inhib. hit(s) with Target = 'Protein-S-isoprenylcysteine O-methyltransferase'
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50183409(CHEMBL3822531)
Affinity DataKi:  1.10E+3nMAssay Description:Competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes using increasing AFC substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Rattus norvegicus)
Institute For Biological Research

Curated by ChEMBL
LigandPNGBDBM50034278(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyls...)
Affinity DataKi:  2.80E+3nMAssay Description:Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systemsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50183409(CHEMBL3822531)
Affinity DataKi:  2.90E+3nMAssay Description:Non-competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes with increasing [14C]-S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174225(((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylsul...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Rattus norvegicus)
Institute For Biological Research

Curated by ChEMBL
LigandPNGBDBM50034280(2-Chloro-5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10...)
Affinity DataKi:  8.00E+3nMAssay Description:Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systemsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Rattus norvegicus)
Institute For Biological Research

Curated by ChEMBL
LigandPNGBDBM50034277(CHEMBL23289 | Thioacetic acid S-((2E,6E)-3,7,11-tr...)
Affinity DataKi:  8.10E+3nMAssay Description:Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systemsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174226(2-acetamido-3-[(2E,6E,10E)-3,7,11,15-tetramethylhe...)
Affinity DataKi:  1.32E+4nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Rattus norvegicus)
Institute For Biological Research

Curated by ChEMBL
LigandPNGBDBM50034276(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyl-...)
Affinity DataKi:  1.49E+4nMAssay Description:Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systemsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174224((R)-2-Acetylamino-3-[(2Z,6E)-7,11-dimethyl-3-(3-me...)
Affinity DataKi:  1.71E+4nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Rattus norvegicus)
Institute For Biological Research

Curated by ChEMBL
LigandPNGBDBM50034279(5-Amino-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-...)
Affinity DataKi:  7.28E+4nMAssay Description:Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systemsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502491(CHEMBL4443354 | US11834430, Compound 41)
Affinity DataIC50:  0.00200nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502491(CHEMBL4443354 | US11834430, Compound 41)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502493(CHEMBL4558383 | US11834430, Compound 81)
Affinity DataIC50:  0.00300nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502489(CHEMBL4583704 | US11834430, Compound 72)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637711(3-methoxy-4-((1-(3- (2-methyl-1H- imidazol-1- yl)p...)
Affinity DataIC50:  0.0800nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502494(CHEMBL4446351 | US11834430, Compound 9)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502494(CHEMBL4446351 | US11834430, Compound 9)
Affinity DataIC50:  0.100nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637738((S)-3-chloro-4-((1- (3-(2-methyl-1H- imidazol-1- y...)
Affinity DataIC50:  0.150nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502488(CHEMBL4449942 | US11834430, Compound 62)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502488(CHEMBL4449942 | US11834430, Compound 62)
Affinity DataIC50:  0.170nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502492(CHEMBL4446048 | US11834430, Compound 8)
Affinity DataIC50:  0.200nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502486(CHEMBL4468997 | US11834430, Compound 5)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502492(CHEMBL4446048 | US11834430, Compound 8)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637731((S)-4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)ph...)
Affinity DataIC50:  0.300nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637758(4-(2-((2-(2- cyclopropyl-1H- imidazol-1- yl)pyridi...)
Affinity DataIC50:  0.390nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637735(3-fluoro-4-(2-((2-(2- methyl-1H- imidazol-1- yl)py...)
Affinity DataIC50:  0.440nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637730((R)-3-methoxy-4- ((1-(3-(1-methyl- 1H-pyrazol-5- y...)
Affinity DataIC50:  0.640nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502489(CHEMBL4583704 | US11834430, Compound 72)
Affinity DataIC50:  0.680nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502490(CHEMBL4464629 | US11834430, Compound 47)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637759((R)-3-methoxy-4- ((1-(3-(2-methyl- 1H-imidazol-1- ...)
Affinity DataIC50:  0.700nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637719(3-fluoro-4-((1-(3-(1- methyl-1H-pyrazol- 5- yl)phe...)
Affinity DataIC50:  0.700nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637742((S)-3-methoxy-4- ((1-(3-(1-methyl- 1H-pyrazol-5- y...)
Affinity DataIC50:  0.810nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637743(4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)phenox...)
Affinity DataIC50:  0.880nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502487(CHEMBL4473893 | US11834430, Compound 15)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502493(CHEMBL4558383 | US11834430, Compound 81)
Affinity DataIC50:  1nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50348075(CHEMBL1800705)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637728((R)-3-fluoro-4-((1- (3-(1-methyl-1H- pyrazol-5- yl...)
Affinity DataIC50:  1nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637706(3-chloro-4-(2-((2-(2- methyl-1H- imidazol-1- yl)py...)
Affinity DataIC50:  1nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502487(CHEMBL4473893 | US11834430, Compound 15)
Affinity DataIC50:  1.10nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637713(3-methoxy-4-((1-(3- (1-methyl-1H- pyrazol-5- yl)ph...)
Affinity DataIC50:  1.20nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637750((R)-4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)ph...)
Affinity DataIC50:  1.5nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637715((S)-3-chloro-4-(2- (3-(2-methyl-1H- imidazol-1- yl...)
Affinity DataIC50:  1.5nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637712(3-methyl-4-((1-(3- (1-methyl-1H- pyrazol-5- yl)phe...)
Affinity DataIC50:  1.60nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50502495(CHEMBL4445788 | US11834430, Compound 40)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human ICMT expressed in baculovirus infected Sf9 insect cells using SAM as substrate preincubated for 30 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637710(4-((1-(3-(2- cyclopropyl-1H- imidazol-1- yl)phenox...)
Affinity DataIC50:  1.60nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637776(4-(2-(3-fluoro-5-(1- methyl-1H-pyrazol- 5- yl)phen...)
Affinity DataIC50:  1.60nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637786(4-(2-(4-bromo-2- fluorophenoxy) ethoxy)-2-(2-methy...)
Affinity DataIC50:  1.70nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637782(3-chloro-4-(2-((2-(1- methyl-1H-pyrazol- 5-yl)pyri...)
Affinity DataIC50:  1.80nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637688(3-fluoro-4-(2-(3-(2- methyl-1H- imidazol-1- yl)phe...)
Affinity DataIC50:  2nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM637800(3-chloro-4-(2-(3-(1- cyclopropyl-1H- pyrazol-5- yl...)
Affinity DataIC50:  2.20nMAssay Description:An ICMT enzymatic assay was developed using Promega's Methyltransferase-GloTMreagents. In the assay, ICMT catalyzes the methylation of the N-Acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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