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Found 184 Enz. Inhib. hit(s) with Target = 'High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B'
LigandPNGBDBM50344013(CHEMBL1780094 | trans-(3R,5S)-N-((6-aminopyridin-2...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50594973(CHEMBL5169811)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of PDE8B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50344014(CHEMBL1779987 | trans-(3R,5S)-1-((5-methyl-2-pheny...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390333(CHEMBL2070733)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344015(CHEMBL1780096 | trans-(3S,5S)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  0.955nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390334(CHEMBL2070735)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390332(CHEMBL2070732)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344019(CHEMBL1780085 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  1.96nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344020(CHEMBL1780116 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  2.91nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344021(CHEMBL1779988 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390373(CHEMBL2070914)
Affinity DataIC50:  3.63nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344022(CHEMBL1780100 | trans-(3S,5S)-5-(3-methyl-1,2,4-ox...)
Affinity DataIC50:  3.86nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344023(CHEMBL1780089 | trans-(3R,5R)-5-(3-methyl-1,2,4-ox...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390335(CHEMBL2070736)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344024(CHEMBL1780097 | trans-(3S,5S)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344025(CHEMBL1780105 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  4.36nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344026(CHEMBL1780111 | trans-(3R,5R)-N-((6-aminopyridin-2...)
Affinity DataIC50:  4.42nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344016(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344018(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344027(CHEMBL1779985 | trans-(3R,5R)-1-((5-methyl-2-pheny...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390366(CHEMBL2070935)
Affinity DataIC50:  6.79nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390324(CHEMBL2070604)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344028(CHEMBL1779990 | trans-(3R,5R)-1-((5-methyl-2-pheny...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344029(CHEMBL1780084 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390313(CHEMBL2070595)
Affinity DataIC50:  10nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390352(CHEMBL2070901)
Affinity DataIC50:  12.1nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344030(CHEMBL1780087 | trans-(3R,5R)-5-(methoxymethyl)-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390367(CHEMBL2070907)
Affinity DataIC50:  13.1nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390309(CHEMBL2070591)
Affinity DataIC50:  14nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390308(CHEMBL2070592)
Affinity DataIC50:  14nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344031(CHEMBL1779986 | trans-(3R,5R)-5-butyl-1-((5-methyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50272569(CHEMBL4128481)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant human PDE8B using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344032(CHEMBL1780086 | trans-(3R,5R)-N-((6-aminopyridin-2...)
Affinity DataIC50:  16.5nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390339(CHEMBL2070769)
Affinity DataIC50:  17.1nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390371(CHEMBL2070912)
Affinity DataIC50:  17.1nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390378(CHEMBL2070919)
Affinity DataIC50:  17.1nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390363(CHEMBL2070932)
Affinity DataIC50:  17.7nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390336(CHEMBL2070737)
Affinity DataIC50:  19nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344033(CHEMBL1780102 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  19.6nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390364(CHEMBL2070933)
Affinity DataIC50:  21.4nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390343(CHEMBL2070773)
Affinity DataIC50:  21.6nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390338(CHEMBL2070734)
Affinity DataIC50:  23nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390329(CHEMBL2070729)
Affinity DataIC50:  23nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390320(CHEMBL2070600)
Affinity DataIC50:  25nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390375(CHEMBL2070916)
Affinity DataIC50:  25.5nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344034(CHEMBL1780090 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  26nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344035(CHEMBL1780104 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)
Affinity DataIC50:  26.2nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390384(CHEMBL2070925)
Affinity DataIC50:  31.5nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390379(CHEMBL2070920)
Affinity DataIC50:  31.7nMAssay Description:Inhibition of PDE8B expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50344036(CHEMBL1780103 | trans-(3R,5R)-5-(3-methyl-1,2,4-ox...)
Affinity DataIC50:  35.2nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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