Compile Data Set for Download or QSAR
maximum 50k data
Found 30 Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 5A'
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM165193(4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen ...)
Affinity DataKi:  1.23E+4nM IC50:  2.49E+4nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM165192(4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(d...)
Affinity DataKi:  1.30E+4nM IC50:  2.64E+4nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM165191(2-Methoxy-4-(nonanamidomethyl)phenyl dihydrogen ph...)
Affinity DataKi:  4.90E+4nM IC50:  9.80E+4nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM165190(2-Methoxy-4-((8-methylnonanamido)methyl)phenyl dih...)
Affinity DataKi:  7.50E+4nM IC50:  1.52E+5nMAssay Description:For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM569234(US11427563, Compound 101 | US11427563, Compound 16...)
Affinity DataIC50:  41nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM569237(US11427563, Compound 104 | US11427563, Compound 28)
Affinity DataIC50:  57nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM569273(US11427563, Compound 14 | US11427563, Compound 157...)
Affinity DataIC50:  200nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50:  689nMAssay Description:Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM569235(US11427563, Compound 10 | US11427563, Compound 102...)
Affinity DataIC50: >1.00E+3nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50240455(CHEMBL1253351)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267892(CHEMBL4088092)
Affinity DataIC50:  4.97E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from C-terminal His6-tagged/N-terminal maltose-binding protein-tagged STAT5A SH2 domain (unknown...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267888(CHEMBL4104462)
Affinity DataIC50:  7.20E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267878(CHEMBL4104019)
Affinity DataIC50:  7.30E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267887(CHEMBL4077592)
Affinity DataIC50:  7.40E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267890(CHEMBL4085646)
Affinity DataIC50:  7.60E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267886(CHEMBL4093849)
Affinity DataIC50:  8.30E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267877(CHEMBL4103576)
Affinity DataIC50:  8.40E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267876(CHEMBL4080740)
Affinity DataIC50:  8.60E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50118228(5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267889(CHEMBL4080219)
Affinity DataIC50:  8.90E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267862(CHEMBL4075745)
Affinity DataIC50:  9.10E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50000029(4-Methyl-8-{4-methyl-3-[3-(3-{3-[2-methyl-5-(4,6,8...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267885(CHEMBL4066274)
Affinity DataIC50:  9.70E+3nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267891(CHEMBL4076474)
Affinity DataIC50:  1.05E+4nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267884(CHEMBL4086096)
Affinity DataIC50:  1.06E+4nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50267875(CHEMBL4062751)
Affinity DataIC50:  1.19E+4nMAssay Description:Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT5A assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
University Of Leipzig

LigandPNGBDBM50446146(CHEMBL3108909)
Affinity DataKd:  464nMAssay Description:Binding affinity to His-tagged STAT5 (unknown origin) by SPR spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed