BDBM18129 (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid::L-[U-14C]Tyr::Tyrosine::US11021454, Compound L-tyr
SMILES: N[C@@H](Cc1ccc(O)cc1)C(O)=O
InChI Key: InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Tubulin--tyrosine ligase (Homo sapiens (Human)) | BDBM18129 ((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.50E+4 | -6.53 | n/a | n/a | n/a | n/a | n/a | 6.8 | 37 |
Binghamton University | Assay Description Inhibition of [3H]-L-tyrosine incorporation into tubulin by enzyme tubulin tyrosine ligase (TTL). | ACS Chem Biol 5: 777-85 (2010) Article DOI: 10.1021/cb100060v BindingDB Entry DOI: 10.7270/Q25H7DM1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Homo sapiens (Human)) | BDBM18129 ((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CHINA PHARMACEUTICAL UNIVERSITY US Patent | Assay Description 11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m... | US Patent US11021454 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM18129 ((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair |