BindingDB PrimarySearch

BDBM81975 4-hydroxyquinoline-2-carboxylic acid::CAS_492-27-3::CHEMBL299155::Kynurenate::NSC_5280455

SMILES: OC(=O)c1cc(O)c2ccccc2n1

InChI Key: InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N

Data: 6 KI 2 IC50 7 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 81975
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
Ciba-Geigy Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a
Corning Inc. Curated by ChEMBL					Assay Description Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation af...				Bioorg Med Chem Lett 22: 4148-52 (2012) Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0
Corning Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM				Bioorg Med Chem Lett 3: 81-84 (1993) Article DOI: 10.1016/S0960-894X(00)80096-7 BindingDB Entry DOI: 10.7270/Q2MK6CTN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.				J Med Chem 35: 3423-5 (1992) Article DOI: 10.1021/jm00096a019 BindingDB Entry DOI: 10.7270/Q2RR1X68
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Vesicular glutamate transporter 3 (Rattus norvegicus)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.30E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Montana Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Vesicular glutamate transporter (VGLUT)				J Med Chem 45: 2260-76 (2002) Article DOI: 10.1021/jm010261z BindingDB Entry DOI: 10.7270/Q2NK3FRR
The University of Montana Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.37E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis				J Med Chem 56: 7084-99 (2013) Checked by Author Article DOI: 10.1021/jm4009373 BindingDB Entry DOI: 10.7270/Q2G16280
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.92E+4	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at human GPR35 expressed in CHO cells assessed as increase in intracellular Ca2+ measured over 20 secs by Aequorin assay				J Med Chem 56: 7084-99 (2013) Checked by Author Article DOI: 10.1021/jm4009373 BindingDB Entry DOI: 10.7270/Q2G16280
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.52E+5	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at human GPR35 by DMR assay				J Med Chem 56: 7084-99 (2013) Checked by Author Article DOI: 10.1021/jm4009373 BindingDB Entry DOI: 10.7270/Q2G16280
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.17E+5	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporte...				J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Aryl hydrocarbon receptor (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Activation of AHR (unknown origin)				J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of alpha7 nAChR (unknown origin)				J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
G protein-coupled receptor GPR35 (Rattus norvegicus)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6.60E+4	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter ...				J Med Chem 56: 5182-97 (2013) Article DOI: 10.1021/jm400587g BindingDB Entry DOI: 10.7270/Q20C4X5B
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Homo sapiens (Human))	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.52E+5	n/a	n/a	n/a	n/a
Corning Inc. Curated by ChEMBL					Assay Description Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay				Bioorg Med Chem Lett 22: 4148-52 (2012) Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0
Corning Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM81975 (4-hydroxyquinoline-2-carboxylic acid \| CAS_492-27-...) Show SMILES OC(=O)c1cc(O)c2ccccc2n1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
Ciba-Geigy Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair