BDBM50052553 (2S)-2-aminohexanedioic acid::(S)-2-aminohexanedioic acid::CHEMBL88804::L-2-aminoadipic acid

SMILES: N[C@@H](CCCC(O)=O)C(O)=O

InChI Key: InChIKey=OYIFNHCXNCRBQI-BYPYZUCNSA-N

Data: 5 KI  12 EC50

PDB links: 15 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50052553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).				J Med Chem 43: 2609-45 (2000) Article DOI: 10.1021/jm000007r BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+6	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonistic activity at mGlu4a receptor expressed in CHO cells				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonistic activity at mGlu2 receptor expressed in CHO cells				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonistic activity at mGlu6 receptor expressed in CHO cells				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonistic activity at mGlu1-alpha receptor expressed in CHO cells				J Med Chem 39: 3188-94 (1996) Article DOI: 10.1021/jm9602569 BindingDB Entry DOI: 10.7270/Q2M909BH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Rattus norvegicus (Rat))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effect on Metabotropic glutamate receptor 6				J Med Chem 40: 3700-5 (1997) Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (RAT)	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effect on Metabotropic glutamate receptor 1				J Med Chem 40: 3700-5 (1997) Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effect on Metabotropic glutamate receptor 2				J Med Chem 40: 3700-5 (1997) Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+6	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effect on Metabotropic glutamate receptor 4				J Med Chem 40: 3700-5 (1997) Article DOI: 10.1021/jm9703597 BindingDB Entry DOI: 10.7270/Q2W66MF9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned metabotropic glutamate receptor 5				J Med Chem 43: 2609-45 (2000) Article DOI: 10.1021/jm000007r BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).				J Med Chem 43: 2609-45 (2000) Article DOI: 10.1021/jm000007r BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1				J Med Chem 43: 2609-45 (2000) Article DOI: 10.1021/jm000007r BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>3.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)				J Med Chem 43: 2609-45 (2000) Article DOI: 10.1021/jm000007r BindingDB Entry DOI: 10.7270/Q2DZ090Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052553 ((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...) Show SMILES N[C@@H](CCCC(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
					More data for this Ligand-Target Pair