BDBM50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE

SMILES: Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1

InChI Key: InChIKey=PHLBKPHSAVXXEF-UHFFFAOYSA-N

Data: 42 KI  12 IC50  2 Kd  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 50073444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP Ki Database									Psychopharmacology (Berl) 114: 559-65 (1994) Article DOI: 10.1007/BF02244985 BindingDB Entry DOI: 10.7270/Q25X27FZ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP Ki Database									Psychopharmacology (Berl) 114: 559-65 (1994) Article DOI: 10.1007/BF02244985 BindingDB Entry DOI: 10.7270/Q25X27FZ
					More data for this Ligand-Target Pair
Norepinephrine transporter (RAT)	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McNeil Pharmaceutical Curated by PDSP Ki Database									J Pharmacol Exp Ther 247: 1032-8 (1988) BindingDB Entry DOI: 10.7270/Q2S75DV7
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McNeil Pharmaceutical Curated by PDSP Ki Database									J Pharmacol Exp Ther 247: 1032-8 (1988) BindingDB Entry DOI: 10.7270/Q2S75DV7
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	84	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McNeil Pharmaceutical Curated by PDSP Ki Database									J Pharmacol Exp Ther 247: 1032-8 (1988) BindingDB Entry DOI: 10.7270/Q2S75DV7
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McNeil Pharmaceutical Curated by PDSP Ki Database									J Pharmacol Exp Ther 247: 1032-8 (1988) BindingDB Entry DOI: 10.7270/Q2S75DV7
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50073444 (2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2...) Show SMILES Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 Show InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	1.94	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McNeil Pharmaceutical Curated by PDSP Ki Database									J Pharmacol Exp Ther 247: 1032-8 (1988) BindingDB Entry DOI: 10.7270/Q2S75DV7
					More data for this Ligand-Target Pair