BindingDB PrimarySearch

BDBM60928 BDBM50130192::L-3,4-dihydroxyphenylalanine::L-DOPA::US11021454, Compound L-dopa::dihydroxyphenylalanine

SMILES: N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI Key: InChIKey=WTDRDQBEARUVNC-LURJTMIESA-N

Data: 10 IC50

PDB links: 27 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 60928
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
lens epithelium-derived growth factor p75 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	PCBioAssay	n/a	n/a	662	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2Q52N9H
					More data for this Ligand-Target Pair
lens epithelium-derived growth factor p75 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	PCBioAssay	n/a	n/a	526	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2KD1WKS
					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	8.40E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibitory activity against mushroom tyrosinase				Bioorg Med Chem Lett 13: 2409-12 (2003) Article DOI: 10.1016/s0960-894x(03)00395-0 BindingDB Entry DOI: 10.7270/Q2HD7W6H
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Oligopeptide transporter small intestine isoform (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	DrugBank Article PubMed	n/a	n/a	1.41E+8	n/a	n/a	n/a	n/a	n/a	n/a
The University of Michigan Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells				J Pharm Sci 88: 347-50 (1999) Article DOI: 10.1021/js980132e BindingDB Entry DOI: 10.7270/Q22V2H6H
The University of Michigan Curated by ChEMBL					More data for this Ligand-Target Pair
Xanthine dehydrogenase (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	US Patent	n/a	n/a	>6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHINA PHARMACEUTICAL UNIVERSITY US Patent					Assay Description 11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...				US Patent US11021454 (2021)
CHINA PHARMACEUTICAL UNIVERSITY US Patent					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting method				Bioorg Med Chem Lett 28: 2856-2860 (2018) Article DOI: 10.1016/j.bmcl.2018.07.030 BindingDB Entry DOI: 10.7270/Q2WM1H2C
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM60928 (BDBM50130192 \| L-3,4-dihydroxyphenylalanine \| L-DO...) Show SMILES N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair