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CHEMBL2047159 CHEBI:1450578

Data: 4 KI  6 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match
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Other Databases links: PubChem cid PubChem sid

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50386802    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein Coupled Receptor 40


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
38.0n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells a...


Citation and Details

More data for this
Ligand-Target Pair
G-protein Coupled Receptor 40


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Reactome pathway
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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
38.0n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membrane...


Citation and Details

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
140.0n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells aft...


Citation and Details

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
140.0n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes ...


Citation and Details

More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Rattus norvegicus)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 93n/an/an/an/a



Shanghai Hengrui Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion


Citation and Details

More data for this
Ligand-Target Pair
G-protein Coupled Receptor 40


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
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PC sid

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n/an/an/an/a 14n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA


Citation and Details

More data for this
Ligand-Target Pair
G-protein Coupled Receptor 40


(Homo sapiens (human))
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 42n/an/an/an/a



Shanghai Hengrui Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR40 transfected in CHO cells by calcium flux assay


Citation and Details

More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
n/an/an/an/a>10000n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR43 expressed in 293 cells assessed as cAMP accumulation after 30 mins by Alphascreen method


Citation and Details

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
n/an/an/an/a>10000n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR120 expressed in CHO cells assessed as calcium influx after 30 mins by FLIPR assay


Citation and Details

More data for this
Ligand-Target Pair
Free fatty acid receptor 3


(Homo sapiens)
CHEMBL2047159
PNG
(CHEBI:1450578)
Show SMILES O.Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 |r|
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid

Similars

AffyNet 
n/an/an/an/a>10000n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR41 expressed in 293 cells assessed as cAMP accumulation after 30 mins by Alphascreen method


Citation and Details

More data for this
Ligand-Target Pair