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Compile Data Set for Download or QSAR

Found 14 hits of ec50 data for complexid = 50000285   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
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n/an/an/an/a 0.0530n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50143282
PNG
((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Show SMILES O=c1cccc2[C@H]3CNC[C@H](C3)Cn12
Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8?,9-/m1/s1
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n/an/an/an/a 11n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161090
PNG
(9-Chloro-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[...)
Show SMILES Clc1ccc2C3CNCC(C3)Cn2c1=O
Show InChI InChI=1S/C11H13ClN2O/c12-9-1-2-10-8-3-7(4-13-5-8)6-14(10)11(9)15/h1-2,7-8,13H,3-6H2
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n/an/an/an/a 28n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161085
PNG
(9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1...)
Show SMILES Brc1ccc2C3CNCC(C3)Cn2c1=O
Show InChI InChI=1S/C11H13BrN2O/c12-9-1-2-10-8-3-7(4-13-5-8)6-14(10)11(9)15/h1-2,7-8,13H,3-6H2
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n/an/an/an/a 31n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161083
PNG
(11,11-dimethyl-6-oxo-7-aza-11-azoniatricyclo[7.3.1...)
Show SMILES C[N+]1(C)CC2CC(C1)c1cccc(=O)n1C2
Show InChI InChI=1S/C13H19N2O/c1-15(2)8-10-6-11(9-15)12-4-3-5-13(16)14(12)7-10/h3-5,10-11H,6-9H2,1-2H3/q+1
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n/an/an/an/a 37n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161086
PNG
(9-Iodo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,...)
Show SMILES Ic1ccc2C3CNCC(C3)Cn2c1=O
Show InChI InChI=1S/C11H13IN2O/c12-9-1-2-10-8-3-7(4-13-5-8)6-14(10)11(9)15/h1-2,7-8,13H,3-6H2
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n/an/an/an/a 45n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161092
PNG
(9,11-Dichloro-1,2,3,4,5,6-hexahydro-1,5-methano-py...)
Show SMILES Clc1cc(Cl)c(=O)n2CC3CNCC(C3)c12
Show InChI InChI=1S/C11H12Cl2N2O/c12-8-2-9(13)11(16)15-5-6-1-7(10(8)15)4-14-3-6/h2,6-7,14H,1,3-5H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161084
PNG
(1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,...)
Show SMILES S=c1cccc2C3CNCC(C3)Cn12
Show InChI InChI=1S/C11H14N2S/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161088
PNG
(11-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[...)
Show SMILES Brc1ccc(=O)n2CC3CNCC(C3)c12
Show InChI InChI=1S/C11H13BrN2O/c12-9-1-2-10(15)14-6-7-3-8(11(9)14)5-13-4-7/h1-2,7-8,13H,3-6H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161087
PNG
(9,11-Diiodo-1,2,3,4,5,6-hexahydro-1,5-methano-pyri...)
Show SMILES Ic1cc(I)c(=O)n2CC3CNCC(C3)c12
Show InChI InChI=1S/C11H12I2N2O/c12-8-2-9(13)11(16)15-5-6-1-7(10(8)15)4-14-3-6/h2,6-7,14H,1,3-5H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161089
PNG
(11-Chloro-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido...)
Show SMILES Clc1ccc(=O)n2CC3CNCC(C3)c12
Show InChI InChI=1S/C11H13ClN2O/c12-9-1-2-10(15)14-6-7-3-8(11(9)14)5-13-4-7/h1-2,7-8,13H,3-6H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM50161091
PNG
(9,11-Dibromo-1,2,3,4,5,6-hexahydro-1,5-methano-pyr...)
Show SMILES Brc1cc(Br)c(=O)n2CC3CNCC(C3)c12
Show InChI InChI=1S/C11H12Br2N2O/c12-8-2-9(13)11(16)15-5-6-1-7(10(8)15)4-14-3-6/h2,6-7,14H,1,3-5H2
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n/an/an/an/a>100n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM86544
PNG
(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Show SMILES CN1CCCC1c1cncc(c1)C#C
Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3
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n/an/an/an/a 5.20E+4n/an/an/an/a



SIBIA Neurosciences Inc.

Curated by PDSP Ki Database


Assay Description
The compound was tested on recombinant human alpha-1-beta-1-gamma-delta cell lines of human embryonic kidney for nicotinic acetylcholine receptor ago...


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha chain/beta chain/delta chain /gamma chain


(Homo sapiens (Human))
BDBM86544
PNG
(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)
Show SMILES CN1CCCC1c1cncc(c1)C#C
Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3
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n/an/an/an/a 5.30E+4n/an/an/an/a



SIBIA Neurosciences Inc.

Curated by PDSP Ki Database


Assay Description
Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes.


Citation and Details
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Ligand-Target Pair