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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 135431   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135431
PNG
(US8846657, 17.6)
Show SMILES FC(F)(F)[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1
Show InChI InChI=1/C28H29ClF3N7O3/c29-18-10-16(12-33-13-18)23-24-19(11-20(34-23)25-36-27(40)42-37-25)35-26(38-8-9-41-22-3-1-2-21(22)38)39(24)14-15-4-6-17(7-5-15)28(30,31)32/h10-13,15,17,21-22H,1-9,14H2,(H,36,37,40)/t15-,17-,21-,22-/s2
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8962611 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JDZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM135431
PNG
(US8846657, 17.6)
Show SMILES FC(F)(F)[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCO[C@@H]3CCC[C@@H]23)CC1
Show InChI InChI=1/C28H29ClF3N7O3/c29-18-10-16(12-33-13-18)23-24-19(11-20(34-23)25-36-27(40)42-37-25)35-26(38-8-9-41-22-3-1-2-21(22)38)39(24)14-15-4-6-17(7-5-15)28(30,31)32/h10-13,15,17,21-22H,1-9,14H2,(H,36,37,40)/t15-,17-,21-,22-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...


US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair