Affinity DataIC50: 558nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMT: 2°CAssay Description:Inhibition of cytochromes P450 (CYPs) 2C9, 2D6 and 3A4 was assessed
using human liver microsomes and CYP-selective substrate metabolism
reactions. ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMT: 2°CAssay Description:Inhibition of cytochromes P450 (CYPs) 2C9, 2D6 and 3A4 was assessed
using human liver microsomes and CYP-selective substrate metabolism
reactions. ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:Inhibition of cytochromes P450 (CYPs) 2C9, 2D6 and 3A4 was assessed
using human liver microsomes and CYP-selective substrate metabolism
reactions. ...More data for this Ligand-Target Pair