BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 242152   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM242152
PNG
(US9415055, (-)2-chloro-N-[2-[2-(difluoromethyl)pyr...)
Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCOCC1
Show InChI InChI=1/C18H19ClF2N4O2/c19-14-4-2-1-3-13(14)18(26)24-11-15(25-5-7-27-8-6-25)12-9-22-17(16(20)21)23-10-12/h1-4,9-10,15-16H,5-8,11H2,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/a7.437



H. Lundbeck A/S

US Patent


Assay Description
Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), NaH2PO42H2O (9.6 mM), HEPES (25 mM), sucrose (280...


US Patent US9415055 (2016)


BindingDB Entry DOI: 10.7270/Q2NC604C
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM242152
PNG
(US9415055, (-)2-chloro-N-[2-[2-(difluoromethyl)pyr...)
Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCOCC1
Show InChI InChI=1/C18H19ClF2N4O2/c19-14-4-2-1-3-13(14)18(26)24-11-15(25-5-7-27-8-6-25)12-9-22-17(16(20)21)23-10-12/h1-4,9-10,15-16H,5-8,11H2,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...


US Patent US9593105 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2R49STH
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM242152
PNG
(US9415055, (-)2-chloro-N-[2-[2-(difluoromethyl)pyr...)
Show SMILES FC(F)c1ncc(cn1)C(CNC(=O)c1ccccc1Cl)N1CCOCC1
Show InChI InChI=1/C18H19ClF2N4O2/c19-14-4-2-1-3-13(14)18(26)24-11-15(25-5-7-27-8-6-25)12-9-22-17(16(20)21)23-10-12/h1-4,9-10,15-16H,5-8,11H2,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 60n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
Cell culture: 293 HEK cells, stably transfected with plasmids capable of expressing human P2X7 receptor, were cultured by standard methods. Cells wer...


US Patent US9593105 (2017)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2R49STH
More data for this
Ligand-Target Pair