Compile Data Set for Download or QSAR
maximum 50k data
Found 8 of ic50 for monomerid = 259423
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50: <0.100nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50: <0.100nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50: <0.100nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50: <0.100nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50:  9nMAssay Description:Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50:  49nMAssay Description:Inhibition of dofetilide binding to flag-tagged human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)
Affinity DataIC50:  57nMAssay Description:Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed