TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Kyung Hee University
Curated by ChEMBL
Kyung Hee University
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of ROS1 by HotSpot assay relative to controlMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Carna Biosciences
Curated by ChEMBL
Carna Biosciences
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of FLT3 by colorimetric analysisMore data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PKCepsilonMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human N-terminal GST-tagged LRRK2 after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TNIK (unknown origin) by ADP glo luminescent assayMore data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant PKCE expressed in Bac-to Bac baculovirus systemMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of CDK1/Cyclin A (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University Of Utah
Curated by ChEMBL
University Of Utah
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human Syk expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK3/Cyclin E (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 1 umol/L ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR2 after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human SykMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant Pim1 expressed in insect cells by HTRFMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3-beta by colorimetric analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetCyclin-K/Cyclin-dependent kinase 9(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center And Research Institute
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 1 umol/L ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant Aurora A expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C gamma type(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human PKCgammaMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of human CHK2 kinase expressed in insect Sf21 cells using phospho-CREBtide as substrate at 30 uMMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Griffith University
Curated by ChEMBL
Griffith University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of Pim2 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 10 umol/L ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 36.3nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of ASK1 (unknown origin) by luciferase assayMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of TNIK-mediated TCF4/beta-catenin transcription in human HCT116 cells by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Universidade Federal Do Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uMMore data for this Ligand-Target Pair
TargetProtein kinase C delta type(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human PKCdeltaMore data for this Ligand-Target Pair
Affinity DataIC50: 49.0nMAssay Description:Inhibition of TYRO3/SKYMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human ZAP70 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of GST-GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair