TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of hypoxia-induced HIF1 transcriptional activity in human HeLa cells measured after 12 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.21E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase r...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Institute Of Pharmaceutical Chemistry
Curated by ChEMBL
Institute Of Pharmaceutical Chemistry
Curated by ChEMBL
Affinity DataIC50: 3.19E+4nMAssay Description:Inhibition of PDE5 from plateletsMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Tokyo Institute Of Innovative Research
Curated by ChEMBL
Affinity DataIC50: 4.84E+4nMAssay Description:Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hy...More data for this Ligand-Target Pair