BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 50149698   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149698
PNG
(CHEMBL3771043 | US10273223, Compound E-1 | US96374...)
Show SMILES CC(C)n1ccc2c(cccc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H23N3O2/c1-12(2)23-9-8-15-16(6-5-7-18(15)23)19(24)21-11-17-13(3)10-14(4)22-20(17)25/h5-10,12H,11H2,1-4H3,(H,21,24)(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...


US Patent US9637472 (2017)


Article DOI: 10.1021/jm021123s
BindingDB Entry DOI: 10.7270/Q2X0693B
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149698
PNG
(CHEMBL3771043 | US10273223, Compound E-1 | US96374...)
Show SMILES CC(C)n1ccc2c(cccc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H23N3O2/c1-12(2)23-9-8-15-16(6-5-7-18(15)23)19(24)21-11-17-13(3)10-14(4)22-20(17)25/h5-10,12H,11H2,1-4H3,(H,21,24)(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....


US Patent US10273223 (2019)

More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149698
PNG
(CHEMBL3771043 | US10273223, Compound E-1 | US96374...)
Show SMILES CC(C)n1ccc2c(cccc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H23N3O2/c1-12(2)23-9-8-15-16(6-5-7-18(15)23)19(24)21-11-17-13(3)10-14(4)22-20(17)25/h5-10,12H,11H2,1-4H3,(H,21,24)(H,22,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Epizyme

Curated by ChEMBL


Assay Description
Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay


J Med Chem 59: 1556-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01501
BindingDB Entry DOI: 10.7270/Q2B56MM7
More data for this
Ligand-Target Pair