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Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 50165859   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))
BDBM50165859
PNG
(CHEMBL3799288)
Show SMILES CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assay


Bioorg Med Chem 24: 2215-34 (2016)


Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))
BDBM50165859
PNG
(CHEMBL3799288)
Show SMILES CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28)
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KEGG

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PC sid
UniChem

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Article
PubMed
n/an/a 112n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assay


Bioorg Med Chem 24: 2215-34 (2016)


Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))
BDBM50165859
PNG
(CHEMBL3799288)
Show SMILES CCCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C21H21F2N7O2S/c1-3-5-12(2)33(31,32)30-15-8-7-14(22)18(16(15)23)29-20-13(6-4-9-24-20)17-19-21(27-10-25-17)28-11-26-19/h4,6-12,30H,3,5H2,1-2H3,(H,24,29)(H,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot method


Bioorg Med Chem 24: 2215-34 (2016)


Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0
More data for this
Ligand-Target Pair