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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = '5-Hydroxytryptamine receptor 6 (5-HT6)' and Ligand = 'BDBM34153'   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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Article
PubMed
4.5 -49.6n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
4.5n/an/an/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.900n/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT6 receptor expressed in HEK293F cells assessed as stimulation of cAMP level after 30 mins by HTRF assay Inhibition of ra...


J Med Chem 52: 675-87 (2009)

More data for this
Ligand-Target Pair