Compile Data Set for Download or QSAR
Found 21 Enz. Inhib. hit(s) with Target = 'Acetylcholinesterase' and Ligand = 'BDBM120262'
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  1.60nMAssay Description:Inhibition constant determined against Acetylcholinesterase (AChE) receptor.Checked by AuthorMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of human RBCMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Mus musculus (mouse))
Mayo Clinic

LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  250nM ΔG°:  -37.7kJ/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  400nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  790nMAssay Description:Dissociation constant for enzyme-inhibitor complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  800nMAssay Description:Inhibition of human erythrocytes recombinant AChE assessed as dissociation constant for enzyme-inhibitor complexMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition constant using AChE or BuChE.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  4.80E+3nMAssay Description:Competitive inhibition of human recombinant AChE using ATChCl as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  4.80E+3nMAssay Description:Dissociation constant for enzyme-inhibitor-substrate complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of human erythrocytes recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complexMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 7.80nMAssay Description:Inhibitory activity against AcetylcholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 50nMAssay Description:Inhibition of Acetylcholinesterase activity of calf forebrainMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 200nMAssay Description:Inhibition of Acetylcholinesterase from human red blood cellsMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 500nMAssay Description:Inhibition of Acetylcholinesterase activity from octopus brainMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 780nMAssay Description:Inhibition acetylcholinesterase (AChE) enzyme.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 3.96E+3nMAssay Description:In vitro inhibitory activity against human recombinant AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human erythrocyte recombinant AChE by modified Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of human recombinant AChE after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(EDROPHONIUM BROMIDE | EDROPHONIUM CHLORIDE | Edrop...)
Show SMILES CC[N+](C)(C)c1cccc(O)c1
Show InChI InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of bovine AChEMore data for this Ligand-Target Pair