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Found 28 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1' and Ligand = 'BDBM82015'
TargetAdenosine receptor A1(BOVINE)
Center For Bio-Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor of calf brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Center For Bio-Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  5.90nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor of rat brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  60nMAssay Description:Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]-cyclohexyladenosine (CHA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  60nMAssay Description:Affinity towards adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  70nMAssay Description:Inhibition of [3H]- PIA binding at adenosine A1 receptor on rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  76nMAssay Description:Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]-PIA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  86nMAssay Description:Binding affinity towards adenosine A1 receptor in rat whole brain membranes using N6-[3H]cyclohexyladenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  86nMAssay Description:Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]-N6-cyclohexyladenosine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  86nMAssay Description:Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  86nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  86nMAssay Description:Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  89nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  89nMAssay Description:Binding affinity for adenosine A1 receptor using [3H]-PIA in rat brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  89nMAssay Description:Binding affinity against Adenosine A1 receptor by displacing [3H]CHA radioligand in rat brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  115nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Center For Bio-Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  200nMAssay Description:Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  350nMAssay Description:Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  400nMAssay Description:Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  760nMAssay Description:Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Center For Bio-Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  3nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  3nMAssay Description:Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]-cyclohexyladenosine as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  8.80nMAssay Description:Binding affinity towards adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  18nMAssay Description:Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  800nMAssay Description:Antagonism of adenosine A1 receptor assessed from the ability to inhibit binding of [3H]-cyclohexyladenosine to rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM82015(1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione...)
Affinity DataIC50:  1.34E+3nMAssay Description:Binding Affinity for Adenosine A1 receptor expressed in CHO-K1 cells compared to [3H]-CCPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed