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Found 1 hit Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive sodium channel alpha-subunit' and Ligand = 'BDBM50190474'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens (Human))
BDBM50190474
PNG
(6-(4-{4-[N'-(3,5-diamino-6-chloropyrazine-2-carbon...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc1
Show InChI InChI=1S/C22H28ClN7O8/c23-16-18(25)29-17(24)11(28-16)19(34)30-22(26)27-8-2-1-3-9-4-6-10(7-5-9)37-21-14(33)12(31)13(32)15(38-21)20(35)36/h4-7,12-15,21,31-33H,1-3,8H2,(H,35,36)(H4,24,25,29)(H3,26,27,30,34)/t12-,13-,14+,15-,21?/m0/s1
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)


Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH
More data for this
Ligand-Target Pair