Found 137 Enz. Inhib. hit(s) with Target = 'Amine oxidase [flavin-containing] B' and Ligand = 'BDBM15579' 
Affinity DataKi: 3.30nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Irreversible inhibition of recombinant human MAO-B expressed in baculovirus infected BT1 cells using benzylamine as substrate at 200 uM preincubated ...More data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Competitive reversible inhibition of human recombinant MAO-B expressed in baculovirus infected BT1 insect cells using p-tyramine as substrate assesse...More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Inhibition of human MAO-B expressed in BTI insect cells using p-tyramine as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...More data for this Ligand-Target Pair
Affinity DataKi: 350nMpH: 7.4Assay Description:Study medium contained 0.1 mL of sodium phosphate buffer (0.05 M, pH 7.4), various concentrations of the newly synthesized compounds or reference com...More data for this Ligand-Target Pair
Affinity DataKi: 380nMAssay Description:Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Reversible inhibition of recombinant human MAOB expressed in Pichia pastoris using varying levels of kynuramine as substrate measured after 5 mins by...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 970nMAssay Description:Reversible inhibition of MAO-B in Wistar rat assessed as inhibition constant followed by using clorgyline as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Inhibition constant against human recombinant Monoamine oxidase-B More data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:MAO A and MAO B activities were determined spectrophotometrically using kinuramine as substrates. Fluorimetric measurements were recorded with a Perk...More data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Inhibitory concentration for human Monoamine oxidase BMore data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Inhibitory activity against monoamine oxidase B in isolated bovine brain mitochondriaMore data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Inhibition of bovine brain MAOB using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorome...More data for this Ligand-Target Pair
Affinity DataKi: 970nMAssay Description:Inhibition of bovine brain mitochondrial MAO-B by fluorometric assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 1.35E+3nMAssay Description:Competitive inhibition of rat liver MAO-B after 60 mins using p-tyramine as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 1.35E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate by spectrophotometry-based Holt methodMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 1.35E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate after 60 mins by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 1.35E+3nMAssay Description:Competitive inhibition of MAOB in rat liver homogenate by spectrophotometricallyMore data for this Ligand-Target Pair
Affinity DataKi: 1.93E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Ample...More data for this Ligand-Target Pair
Affinity DataKi: 1.96E+3nMAssay Description:Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 5.68E+3nMAssay Description:Irreversible inhibition of recombinant human MAOB expressed in Pichia pastoris using varying levels of kynuramine as substrate measured after 5 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of human monoamine oxidase BMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant MAO-B expressed in insect cells by Amplex Red assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant MAO-B using benzylamine hydrochloride as substrate assessed as H2O2 synthesis after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:In vitro ability of the compound to inhibit Monoamine oxidase B activity in rat whole brain in vitroMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rat brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as decrease in H2O2 production using p-tyr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of Sprague-Dawley rat liver MAO-B using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based flu...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus-infected insect cells using p-tyramine as substrate incubated for 30 mins prior to sub...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected insect cells using p-tyraimne substrateMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of MAO-B in mitochondria-enriched Sprague-Dawley rat liver fractions using p-tyramine as substrate incubated for 30 mins prior to substrat...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of MAO-B in rat liver homogenate using [14C]-phenylethylamine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Irreversible inhibition of human MAOBMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 60 minutes preincubation periodsMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Irreversible inhibition of human cerebral cortex MAO-B using [14C]-phenylethylamin as substrate pretreated for 60 mins followed by substrate addition...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using benzylamine as substrate preincubated for 1 h...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 7.08nMAssay Description:Displacement of [3H]-Ro 16-6491 from MAO-B receptor in rat cerebral cortexMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity on rat brain MAO-B.More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]U-69593 binding to recombinant human Opioid receptor kappa 1More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 30 minutes pre-incubation periodsMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 9.90nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 20 minutes pre-incubation periodsMore data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
