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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM116758'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM116758
PNG
(US8637532, 472)
Show SMILES C[C@@H](Nc1ncnc2c(cccc12)C(N)=O)c1cccc(NC(=O)C2CCCC2)c1
Show InChI InChI=1S/C23H25N5O2/c1-14(16-8-4-9-17(12-16)28-23(30)15-6-2-3-7-15)27-22-19-11-5-10-18(21(24)29)20(19)25-13-26-22/h4-5,8-15H,2-3,6-7H2,1H3,(H2,24,29)(H,28,30)(H,25,26,27)/t14-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.120n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair