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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM116938'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))
BDBM116938
PNG
(US8637532, 665)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(NC(=O)C4=CCC(C=C4)N4CCOCC4)c3)ncnc12
Show InChI InChI=1S/C27H28N6O3/c28-25(34)22-5-2-6-23-24(22)30-17-31-26(23)29-16-18-3-1-4-20(15-18)32-27(35)19-7-9-21(10-8-19)33-11-13-36-14-12-33/h1-9,15,17,21H,10-14,16H2,(H2,28,34)(H,32,35)(H,29,30,31)
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Similars

US Patent
n/an/a 0.0800n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair