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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM116495'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM116495
PNG
(US8637532, 176)
Show SMILES NC(=O)c1cc(NC(=O)c2ccncc2)cc2c(NCc3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1S/C23H16ClF3N6O2/c24-18-2-1-12(7-17(18)23(25,26)27)10-30-21-16-9-14(33-22(35)13-3-5-29-6-4-13)8-15(20(28)34)19(16)31-11-32-21/h1-9,11H,10H2,(H2,28,34)(H,33,35)(H,30,31,32)
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Similars

US Patent
n/an/a 680n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair