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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM26281'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM26281
PNG
(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Show SMILES COc1cc2c(Nc3cc(CC(=O)Nc4cccc(O)c4)n[nH]3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C29H35N7O5/c1-40-25-15-23-24(16-26(25)41-11-3-8-36-9-6-19(17-37)7-10-36)30-18-31-29(23)33-27-13-21(34-35-27)14-28(39)32-20-4-2-5-22(38)12-20/h2,4-5,12-13,15-16,18-19,37-38H,3,6-11,14,17H2,1H3,(H,32,39)(H2,30,31,33,34,35)
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PC sid
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Similars

Article
PubMed
140 -38.7n/an/an/an/an/a7.522



AstraZeneca



Assay Description
In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...


J Med Chem 50: 2213-24 (2007)


Article DOI: 10.1021/jm061335f
BindingDB Entry DOI: 10.7270/Q2GQ6W24
More data for this
Ligand-Target Pair