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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM26283'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM26283
PNG
(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Show SMILES COc1cc2c(Nc3cc(CC(=O)Nc4cccc(c4)C(F)(F)F)n[nH]3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C30H34F3N7O4/c1-43-25-15-23-24(16-26(25)44-11-3-8-40-9-6-19(17-41)7-10-40)34-18-35-29(23)37-27-13-22(38-39-27)14-28(42)36-21-5-2-4-20(12-21)30(31,32)33/h2,4-5,12-13,15-16,18-19,41H,3,6-11,14,17H2,1H3,(H,36,42)(H2,34,35,37,38,39)
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Similars

Article
PubMed
13 -44.6n/an/an/an/an/a7.522



AstraZeneca



Assay Description
In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...


J Med Chem 50: 2213-24 (2007)


Article DOI: 10.1021/jm061335f
BindingDB Entry DOI: 10.7270/Q2GQ6W24
More data for this
Ligand-Target Pair