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Found 3 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1' and Ligand = 'BDBM174838'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKi:  190nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged Bcl-xL (unknown origin) preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataIC50:  190nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKd:  170nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In DepthDetails US Patent