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Found 6 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1' and Ligand = 'BDBM50060993'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataIC50: >9.92E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to Bcl-xL by 2D- NOESY analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation for 6 hrs by Caspase 3/7-Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataEC50: >3.15E+4nMAssay Description:Inhibition of Bcl-xl in human U266B1 cells assessed as caspase 3/7 activation in presence of 10 % serum for 6 hrs by Caspase 3/7-Glo luminescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataKd:  3.00E+5nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to BCL-XL (unknown origin) by 15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank