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Found 4 Enz. Inhib. hit(s) with Target = 'Beta-1 adrenergic receptor' and Ligand = 'BDBM25748'
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25748(3-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}et...)
Affinity DataKd:  1.24nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25748(3-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}et...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25748(3-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}et...)
Affinity DataEC50:  0.813nMAssay Description:Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25748(3-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}et...)
Affinity DataKd:  0.331nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed