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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-Secretase (AA 1-460)' and Ligand = 'BDBM136912'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-Secretase (AA 1-460)


(Homo sapiens (Human))
BDBM136912
PNG
(US10231967, Example 134 | US8865911, 134 | US99189...)
Show SMILES CCO[C@H]1CC[C@@]2(Cc3ccc(cc3C22N=C(C)C(N)=N2)-c2cc(cc(c2)C(F)F)C#N)CC1
Show InChI InChI=1/C27H28F2N4O/c1-3-34-22-6-8-26(9-7-22)14-19-5-4-18(13-23(19)27(26)32-16(2)25(31)33-27)20-10-17(15-30)11-21(12-20)24(28)29/h4-5,10-13,22,24H,3,6-9,14H2,1-2H3,(H2,31,33)/t22-,26-,27?
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Similars

US Patent
n/an/a 28n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...


US Patent US10231967 (2019)

More data for this
Ligand-Target Pair