BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM148181'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 2


(Homo sapiens (Human))
BDBM148181
PNG
(US8962616, 9)
Show SMILES Cc1nccc(n1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F
Show InChI InChI=1S/C18H18F2N4OS/c1-10-22-5-4-15(23-10)16-6-11-8-26-17(21)24-18(11,9-25-16)13-3-2-12(19)7-14(13)20/h2-5,7,11,16H,6,8-9H2,1H3,(H2,21,24)/t11?,16-,18+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.00E+5n/an/an/an/a4.537



Pfizer Inc.

US Patent


Assay Description
This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...


US Patent US8962616 (2015)


BindingDB Entry DOI: 10.7270/Q20Z7216
More data for this
Ligand-Target Pair