Compile Data Set for Download or QSAR
Found 2 Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4' and Ligand = 'BDBM284966'
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM284966(4-(3-ethylsulfonylphenyl)-2- methylisoquinolin-1-o...)
Show SMILES CCS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C18H17NO3S/c1-3-23(21,22)14-8-6-7-13(11-14)17-12-19(2)18(20)16-10-5-4-9-15(16)17/h4-12H,3H2,1-2H3
Affinity DataIC50: 910nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM284966(4-(3-ethylsulfonylphenyl)-2- methylisoquinolin-1-o...)
Show SMILES CCS(=O)(=O)c1cccc(c1)-c1cn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C18H17NO3S/c1-3-23(21,22)14-8-6-7-13(11-14)17-12-19(2)18(20)16-10-5-4-9-15(16)17/h4-12H,3H2,1-2H3
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid