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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Chymase' and Ligand = 'BDBM256066'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Mesocricetus auratus (Golden hamster))
BDBM256066
PNG
(US9481672, 248)
Show SMILES Cn1c2ccc(cc2n(C2CC2)c1=O)-n1cc(C(O)=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O
Show InChI InChI=1/C26H21F3N4O5/c1-30-20-9-7-14(11-21(20)32(24(30)37)13-5-6-13)31-12-17(23(35)36)22(34)33(25(31)38)19-10-8-15-16(19)3-2-4-18(15)26(27,28)29/h2-4,7,9,11-13,19H,5-6,8,10H2,1H3,(H,35,36)/t19-/s2
PDB

UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...


US Patent US9481672 (2016)


BindingDB Entry DOI: 10.7270/Q20P0XZ7
More data for this
Ligand-Target Pair