Compile Data Set for Download or QSAR
Found 2 Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50351370'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50351370(CHEMBL1819060)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C23H30N4O/c1-6-16(7-2)24-22-19-9-8-10-20(19)25-23-21(15(4)26-27(22)23)18-12-11-17(28-5)13-14(18)3/h11-13,16,24H,6-10H2,1-5H3
Affinity DataIC50: 37nMAssay Description:Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50351370(CHEMBL1819060)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C23H30N4O/c1-6-16(7-2)24-22-19-9-8-10-20(19)25-23-21(15(4)26-27(22)23)18-12-11-17(28-5)13-14(18)3/h11-13,16,24H,6-10H2,1-5H3
Affinity DataEC50:  170nMAssay Description:Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...More data for this Ligand-Target Pair