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Found 1 hit Enz. Inhib. hit(s) with Target = 'Dihydrofolate Reductase (DHFR)' and Ligand = 'BDBM50041177'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50041177
PNG
(5-((3,4,5-trichlorophenylamino)methyl)furo[2,3-d]p...)
Show SMILES Nc1nc(N)c2c(CNc3cc(Cl)c(Cl)c(Cl)c3)coc2n1
Show InChI InChI=1S/C13H10Cl3N5O/c14-7-1-6(2-8(15)10(7)16)19-3-5-4-22-12-9(5)11(17)20-13(18)21-12/h1-2,4,19H,3H2,(H4,17,18,20,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound for DHFR in Pneumocystis carinii


J Med Chem 37: 1169-76 (1994)


Article DOI: 10.1021/jm00034a015
BindingDB Entry DOI: 10.7270/Q2K64H4G
More data for this
Ligand-Target Pair