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Found 7 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM3530'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  29nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  30nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  201nMAssay Description:Inhibition of EGFR (unknown origin) using biotinylated-PTP1B (Tyr66) as substrate incubated for 5 mins prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  5.10E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed