Found 11 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM50090462' TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.370nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells after 18 to 24 hrs by in-cell Western analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Induction of ERalpha degradation in human T47D cellsMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-alpha (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Induction of ERalpha degradation in human MCF7 cells in phenol red free RPMI medium containing 5% charcoal-stripped FBS incubated for 4 hrs by IRDye ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 0.800nMAssay Description:Induction of ERalpha degradation in tamoxifen-sensitive human MCF7:WS8 cells after 24 hrs by CellTag 700 staining based In-cell western assayMore data for this Ligand-Target Pair
