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Found 6 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM50310381'
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  3.40nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17beta-estradiol-induced alkaline phosphatase activity after 3 days by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  13nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17beta-estradiol-induced alkaline phosphatase activity after 3 days by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310381((S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-d...)
Affinity DataIC50:  174nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed