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Found 4 Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-III' and Ligand = 'BDBM65493'
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Bc Cancer Agency

LigandPNGBDBM65493(eIF4A3 inhibitor, 2)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Bc Cancer Agency

LigandPNGBDBM65493(eIF4A3 inhibitor, 2)
Affinity DataIC50:  110nMAssay Description:Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Bc Cancer Agency

LigandPNGBDBM65493(eIF4A3 inhibitor, 2)
Affinity DataIC50:  200nMAssay Description:Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-III(Homo sapiens (Human))
Bc Cancer Agency

LigandPNGBDBM65493(eIF4A3 inhibitor, 2)
Affinity DataKd:  57nMAssay Description:Binding affinity to full-length human recombinant His6-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed