Found 8 Enz. Inhib. hit(s) with Target = 'G-protein coupled bile acid receptor 1' and Ligand = 'BDBM21675'
Affinity DataEC50: 755nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at wild type TGR5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells measured after 30 mins by cAMP substrate based assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataEC50: 5.74E+3nMAssay Description:Agonist activity at mouse TGR5More data for this Ligand-Target Pair
Affinity DataEC50: 840nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 918nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair