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Found 4 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50214932'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214932((Z)-5-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methy...)
Affinity DataKi:  0.900nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214932((Z)-5-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methy...)
Affinity DataIC50:  0.700nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214932((Z)-5-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methy...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214932((Z)-5-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methy...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed